Longevity and cell biology

Senescence, NAD+, mitochondria and the skin-gut-brain axis.

Skin, gut, cortisol: the barrier under a long stress signal

Sustained cortisol slows epidermal lipid enzymes and shifts the skin's microbial pattern. Postbiotics can sit beside lipids. They do not stand in for sleep.

Julian Vance · 2026-10-06

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Longevity and cell biology

Glycation in the dermis: what carnosine can slow, and what stays

Glucosepane and pentosidine cross-link collagen and stay there. Carnosine and phenols can brake new Maillard chemistry. A cream does not unpick the old bridges.

Julian Vance · 2026-10-05

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Longevity and cell biology

Epigenetic skincare stays on the mark, never on the letters

Peptides can nudge histone enzymes in a model. Copy that claims to rewrite a DNA sequence is false, and it pulls a clinic out of cosmetics.

Dr. Claire Moreau · 2026-10-04

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Longevity and cell biology

Mitochondria in skin: the antioxidants that aim at the organelle

Ascorbic acid stays mostly in the cytosol. MitoQ analogues, PQQ and CoQ10 carriers speak to electron transport, if the vehicle ever gets them there.

Dr. Claire Moreau · 2026-10-03

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Longevity and cell biology

NAD+ in a serum: the molecule, the shelf, the epidermis

NMN and NR fall apart at the surface. Vesicle size, load and a mild pH window decide whether epidermal sirtuin pathways see a precursor at all.

Dr. Claire Moreau · 2026-10-02

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Longevity and cell biology

The cell that stopped dividing and kept the lights on

Senescent fibroblasts stay metabolically busy and release SASP. Fisetin and quercetin remain bench signals until dose, vehicle and pH are real.

Dr. Claire Moreau · 2026-10-01

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